Imara M&A

ELVN-001 is Selective for ABL1 • ELVN-001 has a very selective kinase profile Clean vs. key off-targets in cells 372 kinases screened at 1 µM compound (100 μM ATP) ● ● ● ● ● ELVN-001 is also very clean (>10 µM) in an in vitro safety panel of >130 receptors ELVN-001 Ponatinib Nilotinib Dasatinib Kinases with >50% inhibition selected for IC50 determination >100x window vs. all but 2 kinases profiled Bosutinib CKIT >10,000 30 200 0.6 1,000 Cellular Phosphorylation IC50 (nM) FLT3wt >10,000 3.8 >10,000 >1,000 4,700 PDGFRb >10,000 89 720 7.1 7,900 VEGFR2 >10,000 4.8 2,900 >1,000 >10,000 CSRC >10,000 Reference: Abl kinases are required for vascular function, Tie2, and angiopoietin-1-mediated survival. Pendergast et al. PNAS. 2013;110(30):12432-7. 630 >10,000 10 16 ELVN-001 (100 μM ATP) Kinase ABL1 ABL2/ARG TRKC TNIK LOK/STK10 LRRK2 FGR ACK1 FYN HGK/MAP4K4 LCK IC50 (NM) 1 31 41 110 183 486 550 698 725 973 >1,000 Large window for ABL2/ARG may result in a favorable safety profile 28

View entire presentation