Certara Investor Day Presentation Deck

Ibrutinib case study using Simcyp Simulator Ibrutinib for the treatment of mantle cell lymphoma Source: American Chemical Society Simcyp Modelling Strategy Simcyp model developed in healthy adults using lab and clinical data Simcyp model verified using clinical data with strong CYP3A4 inhibitor & inducer Simulated DDI with moderate CYP3A4 inhibitors & inducers in cancer patients -> recommended dose adjustments 47 CERTARA

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