ATAI Investor Day Presentation Deck

Disability in Schizophrenia is Primarily Caused by Cognitive Impairment Large Medium Small Correlation With Outcome 0.8 0.6 0.4 0.2 0.0 Neurocognitive Deficits P<.0001 Verbal Memory Immediate Memory Executive Functions Community Functioning Instrumental and Problem-Solving Skills Psychosocial Rehabilitation Programs Attention/ Vigilance Composite cognitive scores more strongly related than individual test scores Summary Scores* *Relationship between outcome and summary scores based upon data on file, Dr Michael F Green, and previously presented in Medscape CME Unraveling the complexities of Schizophrenia: New targets, new opportunities. http://www.medscape.orgiview article/763725 transcript. Accessed April 25, 2014. Green MF, et al. Schizophr Bull. 2000;26(1):119-136. 13

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