AstraZeneca Results Presentation Deck

Scope 1 & 2 Decarbonisation through pioneering partnership with Vanguard Renewables Enabling the delivery of renewable natural gas to all US sites by 2026¹ to save: Progressing Ambition Zero Carbon Taking bold action to mitigate climate change through new and expanded initiatives AMBITION ZERO CARBON | on track to deliver absolute reductions in GHG emissions across our value chain 650,000m British thermal units per year 35kt GHG emissions per year AstraZeneca Vanguard CEO Opening Remarks RENEWABLES Scope 3 Financial Results to: Oncology Investing $400m to plant and maintain 200 million trees by 2030 AZ Forest expanding our global reforestation and biodiversity initiative BioPharmaceuticals restore biodiversity build on existing forest projects maximise environmental and community co-benefits sequester carbon Scopes 1, 2, 3 Rare Disease Major initiatives Residual emissions removal Making progress towards our SBTi approved targets² Transition plan focused on major decarbonisation initiatives and residual emissions removal Scope 1 & 2 site efficiency renewable power/heat electric vehicle management of F-gas <2% using bioenergy with carbon capture and storage CEO Closing Remarks 1. By end of 2026. 2. Our net zero scope 1-3 science-based targets have been verified under the Science Based Targets initiative Net-Zero Corporate Standard; reduce our greenhouse gas emissions from our global operations and 29 fleet (Scope 1 and 2) by 98% by early 2026, from 2015 baseline. Reduce our greenhouse gas emissions across our entire value chain footprint (Scope 1, 2 and 3) by 50% by 2030, a 90% reduction by 2045, from 2019 baseline. 3. From 2030. GHG = greenhouse gases; kt = kilo-tonnes; SBTi = science-based targets initiative; NGP = next-generation propellant. - Scope 3 supplier engagement NGP sustainable product design nature-based solutions³, including AZ Forest

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