Kymera Investor Day Presentation Deck
Role of STAT3 in Inflammatory Processes
STAT3 is activated by multiple tyrosine kinases
and plays a critical role in the signaling of
cytokines, hormones, and growth factors
including IL-6, IL-21, IL-11, OSM, TGF-B, VEGF
STAT3 gain-of-function mutations lead to a poly-
autoimmunity with clinical manifestations that
include interstitial lung disease (ILD), arthritis,
scleroderma and eczema
Increased STAT3 activation is associated with
disease severity in chronic
inflammation including SSC, RA, AS, MS, IBD,
Psoriasis
STAT3 activation is also implicated in conditions
defined by intense stromal remodeling in the
absence of overt inflammation, e.g. IPF, PAH,
NAFLD, and Diabetic Kidney Disease
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Leukocyte Activation
OSM, IL-6, IL-27
Tissue
Remodeling and
Fibrosis
KYMERA R&D DAY - December 16th, 2021
OSM, IL-6
Endothelial
Activation
STAT3
IL-6, LIF, IL-11
Stromal Cell Activation
IL-6, IL-21, LIF, IL-11
T Cell and
Macrophage
Differentiation
Leukocyte Recruitment and
Retention
Do o C
Chemokine Production
(e.g. CCL2, CCL11, CXCL10)
Adhesion Molecule Expression
(e.g. ICAM-1, VCAM-1)
Cytokine Production
(e.g. IL-6)
Epithelial
Regeneration and
Cancer
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