Kymera Investor Day Presentation Deck

Ex Vivo Cytokine Stimulation: Methodology in KT-474 Phase 1 Trial Impact of KT-474 on TLR- stimulated Cytokine/Chemokine NH₂ TLRs T KT-474 KYMERA Production MyD88 IRAK4 IRAK1 IRAK2 TRAF6 140 Cytokines/Chemokines PBMCs ©2021 KYMERA THERAPEUTICS, INC. 1 Blood Draw Pre-/Post-Dose R848 or LPS TruCulture Tube 2 Overnight Incubation (37°) 8888 KYMERA R&D DAY - December 16th, 2021 3 Plasma Isolation 4 Cytokine/Chemokine Measurement TNF-a, IFN-y, IL-13, IL-6, IL-8, IL-10, IL-12, IL-17, IL-23 PAGE 29

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