Exact Sciences Comapany Presentation

Drive profitable revenue Core revenue grew 23% in 3Q23 Core revenue $506M +23% $625M Screening revenue 3Q23 $361M +31% $472M $145M Drive profitable revenue Ĉ Invest in world-class talent Provide seamless customer experience -+5%* Offer tests that impact decision-making 2 Precision Oncology core revenue 3Q22 3Q22 3Q23 3Q22 Please refer to the appendix accompanying this presentation for discussion of non-GAAP financial measures and reconciliations to GAAP financial measures EXACT SCIENCES Increase access & drive adoption Generate rock-solid clinical evidence ✓ $153M 3Q23 16

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