ATAI Investor Day Presentation Deck

Wide-spread beneficial qEEG changes at middle and high doses Endpoint Delta (2.0-4.0 Hz) Theta (4.0- 8.0 Hz) Alpha (8.0-12.0 Hz) Alpha 1 (8.0-10.0 Hz) Alpha 2 (10.0-12.0 Hz) Beta (12.0 25.0 Hz), Beta 1 (12.0-15.0 Hz) Beta 2 (15.0- 18.0 Hz) Beta 3 (18.0- 25.0 Hz) Alpha Slow wave index (ASI) Theta-Beta Ratio (TBR) Beta-Alpha Ratio (BAR) Dominant frequency, frontal (IAF1) Dominant frequency, occipital (IAF2) EO Condition Cohort 2 atai LIFE SCIENCES Cohort 4 Cohort 1 (40 mg) (80 mg) (10 mg) FCT POFCTPOFCTPOFCTPO 个 ↑ ↓↓ ↓↓↓↑↑↑↑↑↑↑↑↑ ↓↓↓↓↓ Cohort 3 (20 mg) ↓↓↓↓↓↓↓ ↑↓ ↓↓↓↓↓ ↓↓↓↓ 111111↑↑↑↑↑↑↑↑↑ 个一个个 ↓↑↑↑↑↑↑↑↑↑↑↑↑↑↑ JIJIN NNNNNNNNNNNNNNNTNINN Eyes open qEEG change: day 2 to day 4 Small Large ↑ ↓ → S ↓↑ 7 V ↓↑ Increase only Decrease only Decrease then increase Increase then decrease Variable over time or regions Small <-0.10 or >0.10 Large <-0.15 or >0.15 Nothing >=-0.10 & <=0.10 +0.05 and ±0.10 for 1/F slope Orange-shaded and blue-shaded cells respectively indicate increases and decreases that were significant in the mixed model (MMRM) analysis. Increased alpha/ASI (middle & high doses), decreased beta (lowest dose) | 35

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