Connecting Innovation to Purpose

Log2 Expression (RNA Seq) 15- Validation of Nectin-4 as a Tumor Associated Antigen beyond mUC 24 | bunda : D Mhain wicked D ▬▬ | MAR I ملاحة 1 Source: Corbus data on file, Swiecicki et al., Abstract 6017., ASCO 2023 <---- Other highly expressing tumors ----> U HAN ▬▬ ther PE I ▬▬ H&NSCC UC JU H uvm acc lgg pcpg gbm kirp lihc laml kirc skcm sarc kich meso dlbc thym tgct ucs read coad stad thca ucec prad ov chol paad esca luad brca lusc hnsc cesc blca Elevated Nectin-4 expression: urothelial, breast, ovarian, cervical, colorectal, rectal, esophageal, gastric, lung, thyroid, prostate, cholangiocarcinoma, pancreatic cancer, testicular cancer T IL **** Parameter Confirmed ORR CR PR PADCEV. enfortumab vedotin-ejfv Injection for IV infusion 20 mg & 30 mg vials H&NSCC SD mPFS Patients (N=46) 11 [23.9%) 1 [2.2%) 10 (21.7%) 15 (32.6%) 3.94 months 2023 ASCO ANNUAL MEETING

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