Taysha IPO Presentation Deck

miRARE is a targeting panel for endogenous miRNAs which can regulate various transgenes 1 Viral genome in nucleus 2 mRNA in cytoplasm Transgene Translation and nuclear localization 3 miRNA-responsive target sequence in untranslated region 5 Mature miRNAs bind to mRNA in cytoplasm to regulate its expression Transgene F. In this conceptual loop, the 3'UTR features targets for miRNAs. The viral genome does not encode miRNAs. 4 mature miRNA Transgene drives expression of many endogenous miRNAs miRNA expression 49

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