Evotec Investor Day Presentation Deck

evotec MOLECULE DISCOVERY J.DISCOVERY TM PAGE 92 Billions of human-like antibodies created to screen for activity Transfer learning can bias libraries toward antibodies with superior qualities Example • Discriminator neural network is lightly trained on normal human antibodies • Generator creates antibody structures that sometimes fool the Discriminator, and learns from this experience • Discriminator is trained with more real human antibodies, forcing the Generator to improve • Eventually Generator produces a diverse library of antibodies indistinguishable for human antibodies MOLECULE DESIGN J.MD OAS set- 400,000 per chain Human Antibody Sequences Noise- (Real) Training Sequences EVQLQE... VEIKR QVQLQQ ... VEIKR QVQLVE... VEIKR Generator PROCESS & PRODUCT DESIGN JP3 Discriminator 4* QLQLVE ... VEIKR Generated molecules (Synthetic) Real or Synthetic MANUFACTURING DESIGN J.PODⓇ Screen Diverse library of human-like antibodies (> 109) Libraries containing billions of human-like antibodies are being created to screen for therapeutic activity Target antigen

View entire presentation