Strategic Transformation 2023
RUBY Patients Show Total Hb Rapidly Returning to the Normal Range
and Clinically Meaningful Improvements in HbF Levels of >40%
Mean Total Hemoglobin (g/dL)
editas
MEDICINE
18
16
14
12
10
8
6
4
2
0
9.6
Reni-cel
infusion
4.2%
Baseline
(n=10)
10.9
10.7%
12.3
Day 15t
21.9%
13.0
29.6%
13.8
39.9%
3
1
1.5
2
(n=9) (n=9) (n=8) (n=7)
14.3
47.7%
15.1
48.9%
14.1
14.5 14.6
49.4% 49.5%
46.5%
15.6
47.2%
*Central laboratory reference range. The last RBC transfusion in patients occurred a mean (SD) of 15.4 (6.0) days after reni-cel infusion (n=10).
Hb, hemoglobin; HbF, fetal hemoglobin; RBC, red blood cell; reni-cel, renizgam glogene autogedtem cel; SCD, sickle cell disease.
Hanna R et al. Poster presented at ASH 2023; San Diego, CA, USA, 9-12 December.
16.2
43.4%
10
12
15
4
5
6
8
(n=6) (n=6) (n=4) (n=4) (n=2) (n=2) (n=1)
Months After Reni-cel Infusion
16.9
43.7%
18
(n=1)
Ruby
13.6-18.0 g/dL normal
range in males*
12.0-16.0 g/dL normal
range in females*
Data cutoff November 22, 2023. Number of male patients = 5; number of female patients = 5. Bars show mean Hb (g/dL). Labels inside / next to the bars indicate mean proportion of HbF as a percentage of
total Hb. Mean total Hb concentrations are shown directly above bars.
HbF
Total Hb
Last RBC transfusion, meant
10View entire presentation