BenevolentAI Results Presentation Deck

BEN-8744: potent activity in UC colon biopsies (w/6d)9-11 20000- 15000- 10000- 5000- Endoscopic Biopsy from UC patients DMSO Prednisolone Tofacitinib BEN-3218 Inflammatory cytokine measurement IL-8(pg/ml) 30000- 20000- Colonic mucosa organ culture and compound treatment 10000- DMSO Prednisolone Tofacitinib BEN-3218 Selective PDE10 inhibition showed comparable reduction of IL-6 and IL-8 to the positive controls in ex vivo UC biopsies Cross donor response summary: % inhibition cytokine release (mean % inhibition from N=15 IBD donors) 100- 1 XH 10 100 1000 1 BEN-8744 nM % inhibition IL6 % inhibition IL8 0+ 0.0001 0.001 0.01 100- 0+ 0.0001 0.001 0.1 jtttt 0.01 1 10 BEN-8744 nM 0.1 100 10000 1000 10000 Benevolent 20

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