Ocuphire Pharma Investor Updates

P Synergistic Effects of Nyxol + Low-Dose Pilocarpine (LDP) Combo Nyxol + LDP Demonstrated Efficacy and a Favorable Safety Profile in VEGA-1 Trial 0.75% Nyxol Average PD in photopic conditions is 3.5 to 4.5 mm 28 F O 0.4% 0.4% LDP Source: Ocuphire Clinical Trials Iris Dilator Muscle Inhibition -0.7 to 1+ mm Reduction in PD¹ -1 to 1.5+ mm Reduction in PD Iris Sphincter Muscle Activation Flori Opal Solution, 0.4% Nyxol + LDP 1.5 to 2.5 mm PD reduction moves toward the pin-hole (1.6 to 2.5 mm, up to <3 mm) ≥ 3-line improvement in near vision expected Benefits of Nyxol + LDP: Observed longer durability of effect → inhibition of the dilator muscle with Nyxol may allow sphincter muscle to constrict without opposition and the long-acting effects of Nyxol Lower dose of pilocarpine showed a moderate miotic effect on sphincter muscle Lower dose of pilocarpine showed reduced known side effects such as headaches, browaches, and day/night distance loss Ocuphire PHARMA

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