Ocuphire Pharma Investor Presentation Deck

Nyxol's Differentiated MOA as an Alpha-1 Blocker No Engagement of Ciliary Muscle, No Headaches and Lower Risk of Retinal Detachment Ocuphire PHARMA Phentolamine is the Active Ingredient in Nyxol: a non-selective a Antagonist DILATOR MUSCLE SPHINCTER MUSCLE SPHINCTER MUSCLE Illustration for educational purposes CILIARY MUSCLE Phentolamine blocks a1 receptors on the Iris Dilator Muscle up to 24 hours Decreases pupil size (moderately) without affecting the iris sphincter or ciliary muscles Allows for 3 indications: RM, Presbyopia and DLD 505(b)(2) Regulatory Pathway Supported by Prior Phentolamine Approvals in non-ophthalmic Indications 38

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