Imara M&A

ELVN-001 is a Selective Active Site, Active Form Inhibitor of BCR-ABL 1 I SH3 SH2 BCR Kinase Domain Drug Drug Asciminib ATP-Binding Site ELVN-001 Bosutinib Dasatinib Imatinib Nilotinib Ponatinib Binding Conformation Myristoyl Pocket BCR-ABL Active / Inactive Inactive Active Active Inactive Binding Conformation Inactive Inactive Y BCR SH3 SH2 ATP Y SH1 ATP Competitive BCR-ABL Inhibitors Bosutinib Dasatinib Nilotinib Ponatinib NLS Y=Tyrosine; NLS-Nuclear Localization Signal; SH1-Src Homology 1 Domain; SH2=Src Homology 2 Domain; SH3-Src Homology 3 Domain; DB-DNA-Binding Region; AB=Actin-Binding Region; BCR=Breakpoint cluster region Proline Rich Imatinib ELVN-001 DB AB 26

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