BioNTech Investor Day Presentation Deck

mRNA technology Broad mRNA toolkit built out of deep immunological expertise Multiple mRNA formats Backbone-optimized uridine mRNA (URNA) Cap UTR Antigen Backbone-optimized nucleoside-modified mRNA (modRNA) ש Cap UTR Antigen UTR Cap ww UTR A30-L-A70 Self-amplifying mRNA (saRNA) VUTR Replicase SGP Antigen VUTR A30-L-A70 A30-L-A70 UTR Replicase Trans-amplifying mRNA (taRNA) Cap Cap VUTR Antigen VUTR A30-L-A70 Cap VUTR Cap VUTR A30-L-A70 Antigen Antigen VUTR VUTR A30-L-A70 UTR A30-L-A70 NUM + H Delivery formulations ршит пшит ашит пшит VIININ VAN VIN IN VIN NUM NUM Lipoplex (LPX) Lipid nanoparticles (LNP) Polyplexes Flexible delivery routes Local, intratum oral, tissue-specific, or systemic D 111 D Multi-platform engine More than a decade of mRNA research has led to potency increase of >10,000× and improved persistence BIONTECH 29

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