Connecting Innovation to Purpose

20 Phase 1 Disease Responses 3.6 mg/kg 2.7 mg/kg 1.8 mg/kg 1.2 mg/kg 0.6 mg/kg 0.2 mg/kg 0 PD A 1 2 PD PD PD PD PD PR SD 3 SD PD PR PR SD T 5 SD SD PR 6 7 Cycle number (21 days/cycle) 8 Note: Of the 4 PRs reported, 2 PRs are confirmed and 2 remain unconfirmed TNBC Breast CRC Cervical UC Progressive Disease Stable Disease A Partial Response Treatment ongoing 10 11 SD 12

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