Kymera Results Presentation Deck

Plasma KT-413 Concentration (ng/mL) Plasma PK Showing Dose-Proportional Increase in Exposure 300 100 30 10 0 4 8 12 Cycle 1 Plasma PK 24 KYMERA ©2022 KYMERA THERAPEUTICS, INC. Time (h) 48 DL1: 0.16 mg/kg DL2: 0.32 mg/kg 72 PK Parameter Cmax (ng/mL) AUC inf (ng.h/mL) Vd (L/kg) CL (L/h/kg) t₁/2 (h) 0.16 0.32 mg/kg mg/kg (DL1) (DL2) Cycle 1 140 1360 10.1 0.118 59.3 Cycle 1 493 3490 3.99 0.092 30.2 PAGE 20

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