Connecting Innovation to Purpose
28 days
=
Cycle length
10
Padcev® requires frequent dosing and real-world usage differs from label
Day 1
Day 8
Day 15
Day 22
Day 28
N
Monotherapy PadcevⓇ
1.25
mg/kg
1.25
mg/kg
1.25
mg/kg
dose
holiday
6 months of therapy: =
54 hours of total clinic time / patient
Source(s): 1. PADCEVⓇ Prescribing Information as of Dec 2019, 2. Redacted from Tsingas et al.,
ASCO 2023
Real-world use, dose intensity, and
adherence to PadcevⓇ
Metric
EV use
Number of cycles (median, IQR)
EV dose intensity
Treatments per patient month (mean [SD])
Dosing frequency; treatments per cycle (mean [SD])
Dose (mean, mg/kg [SD])
Change in average dose (mg) from baseline (%)
EV treatment adherence
Received on average > 2 treatments per cycle (%)
Result (N = 416)
5 (2,8)
2.6 [0.6]
2.4 [0.5]
1.1 [0.2]
-9.6 [20.2] %
58.8 [34.4] %View entire presentation