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Investor Presentation

22ND CENTURY ENTERS LARGE GLOBAL HOPS MARKET ■ 22nd Century is leveraging its experience with tobacco and hemp/cannabis, a close hop relative, to accelerate the development of proprietary specialty hop varieties or valuable traits. Industry reliance on high-risk traditional breeding techniques ripe for disruption with new accelerated molecular breeding technologies and gene-editing tools Leveraging research findings from closely related hemp/cannabis plants supports the development of specialty hop varieties with: ▪ Enhanced yield, disease resistance, and other advantageous agronomic traits ▪ Distinctive aroma, flavor, nutraceutical, and medicinal properties Significant European market and new European subsidiary support geographic expansion and provide additional growth opportunities for the Company's tobacco and hemp/cannabis operations 22ND CENTURY GROUP 21
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