Valo SPAC Presentation Deck
Biological discovery: Human-centric target discovery powered by
causal artificial intelligence approaches
Bayesian network
analysis
Valo
最最最意接
2
Presumed loss of
function in
GENE1 has been
associated with
lower circulating
TARGET1 levels
Number of Alleles
Opal is designed to
generate novel
targets for precise
patient
populations
via explainable
methodologies
GENOTYPE
127/247
0
BIOMARKER
3
49/82
1
Number of Alleles
1
0.25
Cumulative Rate of Coronary Artery Disease
0:20
100
200
PHENOTYPE
Presumed loss of function
variants GENE1 has been
associated with lower
prevalence of vascular
disease
300
Metabolite 2
400
BIOLOGICAL
DISCOVERY
Circulating TARGET1
levels were
significantly higher
in vascular disease,
compared to
controls
Data implies causality of
TARGET1 in vascular
disease, which can be
modulated by
GENE1/PROTEIN1 inhibition
and builds foundation for
biomarker-driven trials
2Q21
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