Vaxcyte Corporate Presentation

24 24 VAX-XP: Further Evidence of Potential for Platform Scalability IgG Responses for VAX-XP Comparable to Prevnar 13 & Superior to Polysaccharide-only Serotypes ❖ VAX-XP incorporates VAX-24 strains plus emerging serotypes responsible for significant IPD & antibiotic resistance. * Demonstrates spectra scalability of platform and reproducibility of VAX-XP POC data with conjugates produced at larger scale. 13 Serotypes in Prevnar 13 & Pneumovax 23 11 Serotypes in Pneumovax 23 7 additional XP Serotypes IgG Titer 1 × 104 1 × 10 3 1x102 1 x 101 T 1 × 10º 34 Note: +/-95% confidential interval. 5 (1) VAX-XP, includes all 24 strains in VAX-24 and 7 additional pneumococcal conjugates. (2) PS/Alum = PSs formulated with alum. 6A 6B 7F 9V 14 18C 19A 19F 23F 8 N6 0.11ug VAX-XP 10A 11A 12F 15B 17F 20 22F 33F 0.11ug Prevnar 13 1.1ug PS/Alum

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