Investor Presentation

KEY INITIAL HOPS OPPORTUNITIES Application Agronomic traits/powdery mildew, downey mildew, fusarium, and wireworm (disease resistance/pest resistance) Architecture traits/ratio cone/biomass and lupulin density Consumer traits/Alpha and Beta acids beer are industry drivers Terpenoids/flavonoids (oils) are new flavor drivers Xanthohumol and 8-prenylnaringenin potential nutraceuticals and pharmaceuticals Targeted Benefit Crop loss can be as much as 30% of the yield depending on region and year Success can generate 20-60% increase in yield 22ND CENTURY GROUP Stabilize the content and tailor to meet specific requirements from brewers This trait may have a more significant impact creating new disruptive, unique and proprietary aromatic hops flavor profiles for the brewing industry. Addressing a broad range of opportunities including managing anxiety, inducing calm, addressing sleeping disorders, resolving stomach problems, and other wellness applications 22nd Century is actively engaged in discussions with multiple hops growers and consumer product partners to develop specific desired traits. 19

View entire presentation