Taysha IPO Presentation Deck

Survival of PPT1 KO mice after IT delivery of TSHA-118/ ABO-202 Percent Survival 100 75 50 25 0 3 6 I I I | 1 11 1 9 12 Age (Months) 15 + 18 21 24 1 1 1 1 IT administration of TSHA-118 significantly extended survival of PPT1 KO mice for all ages and at all dose levels Untreated Het * Untreated KO 4 week IT 7x10¹1 vg/mouse 12 week IT 7x10¹¹ vg/mouse

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