Immix Biopharma Investor Presentation Deck
3 Optimal Tumor Binding While Ensuring High Expression
COBRA Binder
COBRA Binder
Leads with
Heavy Chain
Proven
Linker of
Heavy and
Light Chain
Employed
..
IHSL
VH (GGGGS)5 VL
LSH VL
(GGGGS) 5 VH
Biomarker Research
ㅏ -
Source:: Moreno-Cortes E,. et al Front Oncol. 2023; Mazinani M, et al. Biomark Res. 2022.
3.6
1.6
Day 10 CAR-T Expansion
(10^7)
HSL LSH
80
76
Specific Cytotoxicity (%):
JeKo1 (ROR1+) co-culture
HSL LSH
doi: 10.3389/fonc.2023.1200914
"Glycine (Gly) and serine (Ser) residues provide the flexibility necessary
for antigen-binding sites to change conformation and maintain good
stability in aqueous solutions... prevent[ing] formation of secondary
structures and reduc[ing] likelihood of the linker interfering with the
folding and function of the scFv"
September 19, 2022
doi: 10.1186/s40364-022-00417-w
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●●●
IMMIX
S BIOPHARMA
NXC-201 COBRA
Binder: Heavy Chain
- Proven Linker -
Light Chain
Configuration,
enabling:
Rapid,
Sustained CAR-
T Expansion
✓ Improved
Cytotoxicity in
the presence of
antigen
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