Valneva IPO Presentation Deck

High Dose Vaccination Protects Against Challenge-Induced AES V VLA1553-101: High Dose After Single/Re-Vaccination Reactogenicity of High Dose After Single Vaccination Joint pain Muscle pain Fatigue Rash Headache -Mild (Grade 1) High Dose: 3.2*105 TCID 50 30% Swelling 20% 10% 0% Vomiting Valneva - Roadshow Presentation Redness Nausea -Moderate (Grade 2) Induration Fever Pain Tenderness -Severe (Grade 3) B Reactogenicity of High Dose After Re-Vaccination (M6): Protection from AEs Joint pain, Muscle pain Fatigue Rash Headache -Mild (Grade 1) Swelling 30% 20% 10% Vomiting Redness Nausea -Moderate (Grade 2) Induration Fever Pain Tenderness -Severe (Grade 3) April 2021 21

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