Akouos IPO Presentation Deck

Novel AAV Vector Platform with Library of ~38,000 AAVAnc Vectors 16 0.05 Anc80Lib Anc81 Anc80 Anc83 Anc84 Anc82 Anc113 Anc127 Anc126 10 10 43 rh 10 AAV8 rh 43 rh 8 Anc110 cy 2 AAV7 AAV3 AAV38 ch5 hu13 2 AAV6 AAV2 42 2 hu48 hu43 AAV9 AAV1 hu 31 hu 32 rh32 rh33 rh34 AAVA AAV5 Exclusive licenses to a library of approximately 38,000 AAVAncs for the potential treatment of inner ear and hearing related disorders • AAVAnc80, a member of this library, has shown significant advantages over commonly used AAV vectors: AKOUOS CONFIDENTIAL Broad tropism across inner ear cell types, which further expands target landscape Superior transduction efficiency in inner ear cells, which paves the way for dual vector delivery of large transgenes and more available. targets Tropism and transduction advantages open new opportunities to address broader target landscape

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