3Q22 Investor Update

TARGETED APPROACH TO HIGHEST VOLUME AND HIGHEST POPULATED COUNTIES TO MAXIMIZE RESOURCES AND REACH Mesa 4.0% A significant proportion of adult smokers can be reached by focusing on a small number of counties within a state, allowing us to market VLN® in a streamlined and efficient manner. Colorado - 64 Counites Larimer 5.3% Boulder 3.596 Jefferson 10.746 Colorado Weld 5.9% Arapahoe 11.8% El Paso 13.6% Pueblo 4.8% Population Density Population % within top 10 counties # of counties to reach 80% of population % of counties to reach 80% of population Concentration of Adult Smokers % of adult smokers within top 10 counties # of counties to reach 80% of adult smokers % of counties to reach 80% of population 82.5% 10 15.6% 78.7% 11 17.2% https://www.fox21news.com/news/colorado-first-to-sell-low-level-nicotine-cigarettes-authorized-by-fda/ ▾ Weather NEWS Sports by: Alina Lec Posted: Oct 5, 2022/12:36 PM MDT Updated: Oct 5, 2022/01:15 PM MDT SHARE f Colorado first to sell low- level nicotine cigarettes authorized by FDA Mornings 13 Features ▾ VLN cigarettes from 22nd Century Group In to receive a Modified Risk Tobacco Product (FDA). They contain 95% less nicotine than Audience Ⓡ consumption to help smokers smoke less, 31,025 national "There's a revolutionary new option availa31,025 local served Abou KDVR-TV (Denver, CO) - FO Morning News at 7:00am Source: CDC; Current Cigarette Use Among Adults (Behavior Risk Factor Surveillance System) 2019; World Population Review Cigarette Prices by State; Internal Documents Television (COLORADO SPRINGS) - Colorado is the fir addictive levels of nicotine and are clinicalAired on October 5, 2022 at 7:05 AM on KDVR-TV Denver, CO, United States KXRM-TV (Colorado Springs, CC FOX 21 Morning News at 6 95% less nicotine Television Aired on October 5, 2022 at 6:06 AM on KXRM-TV (Colorad Colorado Springs, CO, United States VLN VLN Audience Ⓡ 2,689 national 2,689 local FOR YOUR STY VLN VIN VLN VLN KO FILTER IN SHLESSAGGI Helps you smoke less Edgefield ALERT TO SELL LOW-NICOTINE CIGARETTES DO 14 08/15/2022 PRESIDENT BI 22ND CENTURY GROUP Convenience Store News Bestows 35 Products With 2022 Best New Products Awards Comfort and indulgence items dominate this year's crop of honorees. Susan Durtschi, Past Times Marketing CHICAGO-The winners of this year's Convenience Store News Best New Products Awards represent a dynamic lineup of comfort and indulgent snacks, yummy foodservice offerings, and on-trend beverages. While healthy eating is still an important consume trend, this year's entries focused more on comfort foods and indulgence, compared to previous years when new product entries emphasized attributes such Convenience Store News BEST NEW PRODUCTS AWARDS 2022 8

View entire presentation