Investor Presentation

SECOND QUARTER 2022 FINANCIAL HIGHLIGHTS Net revenues Gross Profit Gross Profit Margin 6/30/2022 $ 10.0M¹ $ 1.0M² 10.0% Tobacco 6/30/2021 $ 8.3M $ 0.5M 5.3% Change 19% 99% 470 bps 1. Revenue from tobacco related products was $10.0 million, an increase of 19% from 2021. 2. Tobacco gross profit margin increase QoQ reflects favorable change in mix of tobacco contract manufacturing volumes. 3. Reflects operations of GVB for approximately half of the second quarter; prior period hemp/cannabis is nil. 4. Excluding the impact of the GVB acquisition, which included $1.0 million of inventory step-up amortization, hemp/cannabis gross profit margin would have been approximately 22%. 22ND CENTURY GROUP Hemp/Cannabis² 6/30/2022 $ 4.5M $(0.1M)³ (1.2%) ³,4 Acquisition of GVB expected to double consolidated revenues 22

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