23andMe Investor Presentation Deck
23ME-00610 (23ME'610) Binds with High Affinity to CD200R1
and Inhibits Immunosuppressive
Signaling
23ME '610 is a fully humanized, effectorless, IgG1
antibody against human CD200R1
23ME '610 binds CD200R1 with high affinity (K₁ < 0.1 nM)
23ME '610 blocks CD200 ligand binding to CD200R1,
resulting in inhibition of immunosuppressive signaling
The restoration of T-cell activity by 23ME '610 was
demonstrated using in vitro models of the tumor
microenvironment
No adverse effects of blocking CD200R1 have been
observed in nonclinical toxicology studies
23ME'610 Activates T-cell Function
by Blocking the CD200R1
Checkpoint
Tumor
Cell
CD200
CD200R1
CD8+
T Cell
+
Suppressed T cell function
Copyright © 2022 23and Me, Inc.
Tumor
Cell
23ME-00610
CD8+
T Cell
↓
Activated T cell
23andMe 46View entire presentation