Immix Biopharma Investor Presentation Deck
Nature of AL Amyloidosis
Diseased AL Amyloidosis Plasma Cells Express BCMA Target On Cell Surface
AL Amyloidosis Is Caused By Malignant Plasma Calls That
Produce Misfolded Amyloid Protein ...
Bone marrow
1) PLASMA CELL/
MATURE B CELL CLONE
Circulation
2) NATIVE
LIGHT CHAINS
Misfolding/
oligomerization
3) AMYLOID
FIBRILS
4) CELL DAMAGE
Target tissues/endothelium
Which Damages Primary Organs Including:
Heart, Liver, Kidney
Heart
• Heart failure with preserved ejection fraction
• Thickened ventricular walls and low voltages
on electrocardiography
• Dysponea at rest or exertion, fatigue
• Hypotension or syncope
• Peripheral oedema
Source: Merlini, G., et al. Nat Rev Dis Primers. Oct 2018, Front. Cardiovasc. Med., Dec 2022, Hemato 2022, 3(1), 47-62; https://doi.org/10.3390/hemato3010005
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IMMIX
S BIOPHARMA
Liver
• Increased alkaline
phosphatase
• Hepatomegaly
Kidney
• Nephrotic range
proteinuria
• Renal failure
• Peripheral oedema
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