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Nuvectis Pharma Investor Presentation Deck

Potent Single Agent Activity in Squamous Cell Cancers Average Tumor Volume (mm³) 700 600 500 400 300 200 100 0 Esophageal Cancer Day 3 Baseline Vehicle Control NXP900 (40 mg/kg) NuvectisPharma, Inc. Day 6 Day 8 Day 10 Day 15 Day 13 Day 17 Time Day 20 Day 22 Day 24 KYSE70 cells (YES1 gene amplification) Day 27 Head and Neck Cancer (tongue) Average Tumor Volume (mm³) 700 600 500 400 300 200 100 0 Vehicle Control NXP900 (40 mg/kg) Baseline Day 3 Day 6 Day 8 Day 10 Day 13 Day 15 Day 17 Day 20 Time Day 22 Day 24 Day 27 Cal27 cells (Heterozygous FAT1 copy loss) 19

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