Bionomics Investor Presentation Deck
Compelling Rationale in a Multifaceted Disorder
✓Enhanced fear extinction
in mice and emotional
recovery in humans
following panic attack
(CCK-4 Trial)
✓Antidepressant effect
trends at early time
points in PTSD patients
(Phase 2B Study)
✓ Antidepressant effects in
rodent model of
depression
Bionomics
INTRUSIVE
* Flashbacks
* Nightmares
SIVE THOUGHTS
Physiological
reactions to
trauma
reminders
* Anhedonia
* Social
withdrawal
COGNITIONS & MOOD
BNC210 FOR PTSD
MECHANISM &
PHARMACOLOGY OF
BNC210 (PRECLIN / CLIN)
SUPPORT ITS THERAPEUTIC
POTENTIAL FOR SEVERAL
PTSD SYMPTOMS
* Negative
perception of
self and world
Avoiding
trauma-related:
* People
* Places
AVOIDANCE
x Activiti
es
* Irritability
* Aggression
* Hypervigilance
* Problems
* Sleep
concentrating
disturbances
✓ Reduced threat avoidance
behavior in humans (GAD
Phase 2) and several animal
models of (threat)
✓ Reduced number and intensity
panic symptoms and intensity
in humans (CCK4 challenge
Phase 1)
✓ Reduces amygdala hyperactivity -
a feature shared by patients with
anxiety and/or PTSD (GAD Phase 2)
✓ Reduced anxious behavior in rodent
models
✓ Inhibition of a7 nAChR inhibits
release of excitatory
neurotransmitters - potential to
reduce NA induced hyperarousal (in
vivo micro-dialysis in rat)
AROUSAL & REACTI
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