Evotec Investor Day Presentation Deck

evotec MOLECULE DISCOVERY J.DISCOVERY PAGE 91 TM GAN technology to create human-like antibodies 100,000s of natural human antibody sequences in the public domain serve as the training set Example • Discriminator neural network is lightly trained on normal human antibodies MOLECULE DESIGN J.MD OAS set- 400,000 per chain Human Antibody Sequences (Real) Training Sequences EVQLQE... VEIKR QVQLQQ ... VEIKR QVQLVE... VEIKR Noise- PROCESS & PRODUCT DESIGN JP3 Generator Discriminator • Generator creates antibody structures that sometimes fool the Discriminator, and learns from this experience • Discriminator is trained with more real human antibodies, forcing the Generator to improve • Eventually Generator produces a diverse library of antibodies indistinguishable for human antibodies We can use GAN technology to create human-like antibodies - indistinguishable from normal human antibodies 43 QLQLVE ... VEIKR Generated molecules (Synthetic) MANUFACTURING DESIGN J.PODⓇ Real or Synthetic Human-like antibody

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