BioAtla Investor Presentation Deck
Continued promising safety and tolerability profile in sarcoma
Phase 2 at the RP2D 1.8 mg/kg Q2W
Characteristic
Any Adverse Events (AES)
Related AEs with CTCAE¹ Grade 3 or 4²
Any related serious AEs²
Related AEs leading to death²
Related AEs leading to treatment
discontinuation²
bicatla
Constipation
Peripheral Neuropathy
BA3011
(N=73)
69 (94%)
20 (27%)
5 (7%)
Diarrhea
0
4 (5%)
BA3011 + Opdivo
(N=26)
24 (92%)
10 (39%)
5 (19%)
0
Grade 1-2 (21%)
Grade 3 (1%)
All Grade 1-2 (16%)
1 (4%)^
Grade 3-4 (0%)
Grade 1-2 (16%)
Grade 3-4 (0%)
Low-grade constipation observed is consistent with baseline levels seen in advanced cancer patients
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I
No treatment-related deaths
Few treatment-related SAESs, consistent with
MMAE-based toxicity, including reversible
myelosuppression, transient liver enzyme
elevation, metabolic disturbances
Very few related AEs leading to treatment
discontinuation
No clinically meaningful on-target toxicity
observed over background
Differentiated profile due to avoiding on-target
off-tumor toxicity
Interim data- Data cut-off of Jan 18, 2023
1CTCAE: Common Terminology Criteria for Adverse Events. The NCI Common Terminology Criteria for Adverse Events is a descriptive terminology which is utilized for Adverse
Event (AE) reporting. A grading (severity) scale is provided for each AE term. 2As assessed by the investigator. Missing responses are counted as related. §Grade 2 peripheral
neuropathy; pancreatitis; ^grade 2 lleus
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