Bionomics Investor Presentation Deck
Tackling the Profound Disease Burden of Post-Traumatic Stress Disorder
PTSD Represents a Significant Unmet Need
✓ 70% of people will experience a traumatic event in
their lifetime, but most people recover normally
✓ PTSD results from exposure to actual or threatened
death, serious injury or sexual violence
✓ Affects up to 8% of adults during their lifetime¹
✓ PTSD is a global mental health problem that is
associated with significant morbidity and mortality
and shows up in all facets of peoples' lives
✓ No newly approved pharmacotherapy in almost
two decades
✓ Medications with a novel mechanism of action that
can address the pathophysiology of PTSD are needed
Bionomics
~21M
1.
8% of adults at
some point in
their lives
~9M
3.4%
prevalence
in adults
Unmet medical need to large patient population
Advancement in care
No branded competition
Ability to potentially achieve large market share
Kilpatrick, D., Resnick, H., Milanak, M., Miller, M., Keyes, K. and Friedman, M., 2013. National Estimates of Exposure to Traumatic Events and PTSD Prevalence Using DSM-IV and DSM-5 Criteria.
Journal of Traumatic Stress, 26(5), pp.537-547; 2 Mayo LM, Asratain A., Lindé J et al. Elevated Anandamide, Enhanced Recall of Fear Extinction, and Attenuated Stress Responses Following
Inhibition of Fatty Acid Amide Hydrolase: A Randomized, Controlled Experimental Medicine Trial. Biol Psychiatry. 2020 Mar 15; 87(6): 538-54
2. Only 20 to 30% of PTSD patients achieve clinical remission on SSRI therapies.
US Census Bureau. https://www.census.gov/library/stories/2021/08/united-states-adult-population-grew-faster-than-nations-total-population-from-2010-to-2020.html
~7M
75% of adults
inadequately
treated ²
Opportunity
for BNC210
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