Kymera Results Presentation Deck

Mean % Change in AN Count (+/- S.E. of Mean) Mean % Change in Total AN Count Over Time 0 -10 -20 -30 -40 -50 -60 AN Count: Mean 46 to 51% and Max 100% Reduction AN 0/1/2 Responders: 42 to 50% Response Rate KYMERA 7 -27.4 -All HS (n=12)* 14 -19.9 -49.6 21 Day -31.6 28 Ⓒ2022 KYMERA THERAPEUTICS, INC. -45.4 -Moderate to Severe (n=10) -40.6 -46.1 35 -50.7 42 *One patient is censored for Day 35 and Day 42 since the patient started on ustekinumab, steroids and abx on Day 34. % of Patients with AN 0/1/2 (80% CI) 80 70 60 50 40 30 20 10 0 0 % of Patients with AN Count 0/1/2 7 20 14 17 All HS (n=12) 21 Day 50 28 42 50 35 42 Moderate to Severe (n=10) 40 33 42 PAGE 52

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