BioNTech Investor Day Presentation Deck

2 COVID-19 variants monitoring and prediction Digital & AI/ML Predicted scores for immune escape and fitness prior correlate with in vitro data Wuhan RBD NTD RBD Beta (B.1.351) NTD RBD Omicron (BA.1) NTD Side view A n A Beguir K, et al. bioRxiv 2021; doi: 10.1101/2021.12.24.474095. Top view Distinct epitopes Evaded epitopes 336 300- 200 100 1 336 300- 200 100 PVNT50 Reduction PVNT50 Reduction 00% B0% 40% 0% 0% 80% 60% 40% 20% 0% B.1.1.290 WT 0 8.1.1.298 WT B.1.429 D B.1.258 9.1429 B.1.817.1 8.1.17 B.1.617.1 B.1.517 B.1.817.2 C.SP AV1 8.1.1.7+E484K C.37 8.1258 8.1.517 C.37 Epitope Alteration Score 50 B.1.351" 81.526 B.1.160 B.1.526 P.1 A.VOLV2 50 B.1.351 B.1.162 8.1.1.7 B.1.351 Immune Escape Score 81.351 0.11740084K 8.16172 B.1.351 BA.1 BA2-> AY.1 C.37 BA.2 B.1.351 AVOI.V2 BA.1 100 100 1 DVNT50 Reduction Dissociation Constant, KD (nM) 16 80% 40% 20% 1.00-8 8.0e-9 6.00-9 4.00-9 2.00-9 0.010 8.1.1.299 WT B.1429 8.1.617.1 0 0 P.1 K417N 1452R 0 C.37 B.1.100 8.1.351" 8.1.528 K417N/L452R/T478K 8.1.517 B.1.258 8.14172 Semantic Change Score V367F 5477N "L452R/T478K L4520/F4909 50 WT N501Y 81.351 81174E484K BA:10 K417T/E484K/N501Y E484K BA.16 GA2 ACE2 Binding Score AY.1 AVOLV2 E4840 TATSK 00 B.1.301 B.1.1.7 C.37 N439K L452R/E4840 K417N/E484K/N501Y S477N/E484K Y453F ● 100 E484K/N501Y 100 InstaDeep™ BIONTECH 44

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