Ocuphire Pharma Investor Update

RM Mean Pupil Diameter Over Time Nyxol Treatment Significantly Reduced PD Starting at 1 Hour Post-Dose Through 6 Hours Mean Pupil Diameter (mm) 9 8 7 6 5 4 3 p<0.0001 Max dilation; Mydriatic Treatment rT 0 -1 0.5 p<0.0001 Mean PD - Study Eye (mITT) p<0.0001 MIRA-3 Phase 3 Trial KH p<0.0001 Placebo (n=124) p<0.0001 1.5 2 3 4 Time Post-Treatment with Nyxol/Placebo Source: MIRA-3 Table 14.2.2.1 (mITT). The p-values are change from max pupil dilation treatment compared to placebo. 20 Data includes all three mydriatics (Phenylephrine, Tropicamide, Paremyd). Standard Error bars are shown. -Nyxol (n=244) KH p<0.0001 6 p<0.0001 24 Ocuphire PHARMA

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