Taysha IPO Presentation Deck

Dose-dependent improvements observed in rotarod assessments in mice treated with TSHA-101 Distance (cm) 3000 2000 1000 8 10 12 14 16 Heterozygote/Vehicle Knockout/2.5x10¹¹ total vg Knockout/1.25x10¹1 total vg 18 20 24 Time (weeks) T 28 32 36 Knockout/0.625x10¹1 total vg Knockout/Vehicle 40 44 7 48 52 * 20

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