23andMe Investor Day Presentation Deck

PD-1 is a Negative Regulator of the CD226 Axis Inhibition of CD96 and TIGIT may enhance PD-1 activity - Activating/co-stimulatory interaction - Inhibitory interaction CD112 PVRIG APC/Tumor TIGIT CD155 PD-L1 CD226 CD96 PD-1 T/NK cell ● CD226 activates NK/T-cells PD1 directly regulates CD226 activity TIGIT and CD96 indirectly suppress CD226 ● ● Combining inhibitors (anti- PD-1, anti-CD96, anti-TIGIT) may have more activity that anti-PD-1 alone Copyright © 2022 23andMe, Inc. 23andMe® 45

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