Evotec Investor Day Presentation Deck

evotec 90% of all drugs fail in late stages of clinical development Drug induced liver injury (DILI) is a major contributor for drug failure • The liver is the most frequent site of adverse drug reactions - 18% of marketed drug withdrawals are due to DILI alone PAGE 63 • Animal models predict only approximately 50% of the human DILI events - More predictive models are urgently needed Primary human liver cultures combined with transcriptomics and AI/ML supported analysis - Opportunity to transform DILI prediction 90₂ % of drugs fail in late clinical development 18% drug withdrawals from the market caused by DILI US$ 2.6 and 15 years to develop a drug billion nly 50% DILI picked up in animal studies

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