23andMe Investor Day Presentation Deck
Breadth of Phenotyping Provides Deeper Genetic
Understanding Across Multiple Diseases
PheWAS = Phenotype Wide
Association Study
Every SNP in the genome can be
interrogated at >1,000 medically
related phenotypes
Besides the role of a gene in a
disease of interest, we can use
genetics to learn potential
indication expansions or
possible unwanted effects
Phenotypes
associated
with ABO
blood type
hemorrhoids-
icp bruse easily
thyroid removed-
uker-
hypocoagulation-
cout-
dvertcuts-
high blood pressure-
ignorovirus ever-
icb.nose bleeds-
igbwhooping cough-
kichey stones-
menorthagia-
nosebleed after12-
thyroid cancer_dk_or_fh-
thyroid cancer-
mumps-
mesquito be more-
idbinfluenza last 12m-
any skin cancer-
any_non_mellanoma_skin_cancer
blood dets-
arterial thrombosis_de_or_th
any plant allergy-
iqbstratch_marks-
any_ashma-
stroke-
peripheral artery dis-
hypothyroidism
er positive breast cancer-
Cumart_authra-
antiphospholipid syndrome -
anemia pregnancy healthy control-
algic athra-
anemia-
heart failure-
blood
sugar mack-
blood thinner meds-
chap van thrombosis
gallstories_or_gall bladder_removal
heart attack
high_chell-
high_cholesterd broad-
high Id-
high pisems glucose-
HP allergies
hyperglycemia
ibchildhood ear infections-
icb galstores
igb lipoma-
icblow_hd-
iqbuvaricose veins legs-
juvenile asthma-
juvenile asthme not current-
myocardial infarction de or th
pancreatic cancer_ds or fh-
pulmeny e
-
pulmonary embolism_ck_or_fh-
hints-
stroke cke or th-
superficial thrombophlebitis de or fh-
t2d-
12d_bread-
tonsillectomy
perials
any food allergy-
migraine diagnosis
any animal allergy-
early onset heart attack-
nafid-
savere_aone-
cach
andoratrici-
chronic_hives-
transient ischemic attack_d_or_th-
signed log(p)
-105D5 10
maB176719G_GC
Phenotypes with
increased risk
from having the 'O'
blood type
Phenotypes with
decreased risk
from having the 'O'
blood type
Color intensity indicates statistical
significance of association.
23andMe®
Copyright © 2022 23andMe, Inc.
31View entire presentation