23andMe Investor Day Presentation Deck

Breadth of Phenotyping Provides Deeper Genetic Understanding Across Multiple Diseases PheWAS = Phenotype Wide Association Study Every SNP in the genome can be interrogated at >1,000 medically related phenotypes Besides the role of a gene in a disease of interest, we can use genetics to learn potential indication expansions or possible unwanted effects Phenotypes associated with ABO blood type hemorrhoids- icp bruse easily thyroid removed- uker- hypocoagulation- cout- dvertcuts- high blood pressure- ignorovirus ever- icb.nose bleeds- igbwhooping cough- kichey stones- menorthagia- nosebleed after12- thyroid cancer_dk_or_fh- thyroid cancer- mumps- mesquito be more- idbinfluenza last 12m- any skin cancer- any_non_mellanoma_skin_cancer blood dets- arterial thrombosis_de_or_th any plant allergy- iqbstratch_marks- any_ashma- stroke- peripheral artery dis- hypothyroidism er positive breast cancer- Cumart_authra- antiphospholipid syndrome - anemia pregnancy healthy control- algic athra- anemia- heart failure- blood sugar mack- blood thinner meds- chap van thrombosis gallstories_or_gall bladder_removal heart attack high_chell- high_cholesterd broad- high Id- high pisems glucose- HP allergies hyperglycemia ibchildhood ear infections- icb galstores igb lipoma- icblow_hd- iqbuvaricose veins legs- juvenile asthma- juvenile asthme not current- myocardial infarction de or th pancreatic cancer_ds or fh- pulmeny e - pulmonary embolism_ck_or_fh- hints- stroke cke or th- superficial thrombophlebitis de or fh- t2d- 12d_bread- tonsillectomy perials any food allergy- migraine diagnosis any animal allergy- early onset heart attack- nafid- savere_aone- cach andoratrici- chronic_hives- transient ischemic attack_d_or_th- signed log(p) -105D5 10 maB176719G_GC Phenotypes with increased risk from having the 'O' blood type Phenotypes with decreased risk from having the 'O' blood type Color intensity indicates statistical significance of association. 23andMe® Copyright © 2022 23andMe, Inc. 31

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