AMD Results Presentation Deck

24 APPENDICES Reconciliation of GAAP to Non-GAAP Gross Profit and Gross Margin (Millions) (Unaudited) GAAP gross profit GAAP gross margin % Stock-based compensation Acquisition-related costs (1) Amortization of acquired intangible assets Non-GAAP gross profit Non-GAAP gross margin % Reconciliation of GAAP to Non-GAAP Operating Expenses Q4'21 Q1'21 1,950 $ 929 $ 1,223 33% 27% 25% 170 84 111 141 15 9 293 1,346 $ 23% (Millions) (Unaudited) GAAP operating expenses GAAP Operating Expenses/Revenue % Stock-based compensation Acquisition-related costs (1) Q1'21 Q2'21 Q3'21 Q4'21 Q1'22 Q2'20 Q3'20 Q4'20 $ 848 $ 1,230 $ 1,451 $ 1,587 $ 1,830 $2,086 $ 2,426 $ 2,818 44% 44% 45% 46% 48% 50% 48% 48% 2 2 1 1 1 1 4 92 186 $ 850 $ 1,231 $ 1,452 $ 1,588 $ 1,832 $2,087 $ 2,427 $ 3,100 44% 44% 45% 46% 48% 48% 53% 50% Amortization of acquired intangible assets Non-GAAP operating expenses Non-GAAP Operating Expenses/Revenue % $ $ Q1'22 830 $ 24% 1,103 23% 1 I (1) Acquisition-related costs primarily comprised of transaction costs, purchase price adjustments for inventory and certain compensation charges. Q1 2022 FINANCIAL RESULTS | MAY 3, 2022 AMD

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