Bionomics IPO Presentation Deck

BNC210 Phase 2 in GAD Observed to Have Acute Anxiolytic Activity 300 mg 24 GAD Patients 4 WAY CROSSOVER Significantly reduced activation of Em L&R amygdala caused by viewing fearful faces (L: p<0.05; R: p<0.01) BNC210 300 mg BNC210 2000 mg Lorazepam 1.5 mg Placebo Contrast estimate Significantly reduced connectivity (()) between amygdala and ACC while viewing fearful faces (p<0.05) 1.0 0.8 0.6 0.4 0.2 0.0 -0.2 Placebo Seed hemisphere Left Right Fearful Faces 300 mg fMRI Monitoring 0.5- Significantly reduced threat avoidance behavior of anxious subjects in the JORT behavioral task Mean Intensity of Defensive Behavior 0.4- 0.3- 0.2- 0.1- 0.0 Performed 'JORT' Placebo P=0.165 P=0.007 Lorazepam Error Bors= SEM 300 mg -BNC210 Bionomics seta Bological Psychiatry 2020 fhttps://doi.org/10.1016/4biopsych 2019 12012) Perkins A et al, Translational Psychiatry 2021 (Ittps://dokorg/10.1038/54-1398 -020-01141-51 GAD-Generalized Anxiety Disorder JORT=Joystick Operated Runway Task MRI Functional Magnetic Resonance imaging Amygdala activation is an imaging surrogate for anxiety Connectivity between the amygdala and Anterior Cingulate Cortex (ACC) is very strong in high anxiety P=0.033 2000 mg 12

View entire presentation