ATAI Investor Presentation Deck

Anxiety Opportunity Overview Anxiety disorders develop when feelings of apprehension and unease persist over an extended period and potentially worsen over time Generalized Anxiety Disorder (GAD) Panic Disorder Anxiety in numbers Social Anxiety Disorder (SAD) Post- Traumatic Stress Disorder (PTSD) Obsessive- Compulsive Disorder (OCD) ~40m Anxiety disorder sufferers of in the US #1 Most common mental health disorder in the US¹ ~$42bn Annual societal cost of anxiety disorders in the US³ (1) National Alliance on Mental Illness (2021) (2) Anxiety and Depression Association of America (2021) (3) DeVane et al., "Anxiety Disorders in the 21st Century: Status, Challenges, Opportunities, and Comorbidity With Depression", AJMC (2005) MASSIVE UNADDRESSED NEED ~7m <50% -50% 3 27 GAD sufferers in the US Approximately 7 million individuals suffer from GAD in the US on an annual basis² Low treatment rate Less than half of patients with anxiety disorder in the US receive treatment Anxiety & depression are complimentary It is estimated that half of patients diagnosed with depression also suffer from an anxiety disorder Limited treatment options Currently SSRIs, Benzodiazepines, or Psychotherapy are the only treatment options for anxiety disorder

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