Akouos IPO Presentation Deck

Our Disciplined Candidate Selection Criteria Allow Us to Focus Resources on Promising Targets Covering a Range of Inner Ear Disorders Patient populations with high unmet need 35 Promising preclinical data Large potential market opportunity Hair Cell Targets Supporting Cell Targets Secreted Proteins Clear endpoints with potential for rapid. clinical read-out CONFIDENTIAL AKQUOS Leverage platform established in AK-OTOF to utilize learnings to mitigate development risk Demonstrate platform breadth and balanced risk profile at portfolio level

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