23andMe Investor Presentation Deck

CD200R1 is expressed on from The Cancer Genome Atlas (TCGA) tumor-infiltrating lymphocytes (TILs) CD200R1 expression (using RNAseq data from TCGA) is correlated with several immune cell markers: CD4, CD8, CD45 (shown), and CD11b CD200R1 is co-expressed with antigens or markers that are expressed on lymphocytes seen in most cancer types Log(CPM+0.05) of CD45 CD200R1 correlation with CD45 (hematopoietic cells) 2.5 tho 0.86 2.0- 1.5- 1.0- 0.5- KIRC -1.0 -0.5 0.5 1.0 1.5 Log(CPM+0.05) of CD200R1 1. Clear cell renal carcinoma (KIRC) is shown and was chosen because it had high immune infiltration in the TCGA dataset TCGA, The Cancer Genome Atlas; TILs, tumor infiltrating lymphocytes 23and Me 42 Copyright © 2022 23and Me, Inc.

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