Ocuphire Pharma Investor Day Presentation Deck
RM
55
MIRA-2: Mean Pupil Diameter Over Time by Mydriatic Agent
Nyxol Reduced Pupil Diameter with All Mydriatic Agents; More Rapidly with Phenylephrine as Expected
Pupil Diameter (mm)
9
8
4Mydriatic
3
Max pupil dilation,
Treatment
-1
Phenylephrine (Study Eye)
Mean Pupil Diameter
p<0.0001
p<0.0001
0 0.5 1
p<0.0001
MIRA-2 Phase 3 Trial
Nyxol Reduced PD Faster Across All Mydriatic Agents
F4
KA
p<0.0001 p<0.0001
K
Nyxol n=56
Placebo n=55
p<0.0001
2
3
4
Time Post-Treatment with Nyxol/Placebo
(Hours)
6
Source: MIRA-2 TLR table #14.2.2.3 (mITT). Standard Error bars are shown.
p<0.0001
24
Pupil Diameter (mm)
9
8
3
Mydriatic
-1
Tropicamide or Paremyd (Study Eye)
Mean Pupil Diameter
p<0.0001
Max pupil dilation,
Treatment
p<0.0001
0 0.5 1
p<0.0001
H
p<0.0001
F 1
p<0.0001
-Nyxol n=38
Placebo n=36
HA
p<0.0001
5
2 3 4
Time Post-Treatment with Nyxol/Placebo
(Hours)
6
7
p<0.0001
24
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